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Neospirini + C #10 sachets
 Nonsteroidal anti-inflammatory Vitamin C +
 Nonsteroidal anti-inflammatory Vitamin C +
Dosage form: Effervescent powder.
Generic name: acetylsalicylic acid + ascorbic acid)
Pharmacological effects: nonsteroidal anti-inflammatory Vitamin C +
One of the contents of the package consists of:
_ 400 mg acetylsalicylic acid;
_ 240 mg ascorbic acid;
Sodium hydrogen carbonate, citric acid, sodium carbonate, saccharin, orange flavoring, calcium phosphate, polyvinylpyrrolidone;
Mode of action: acetylsalicylic acid, nonsteroidal anti-inflammatory way, has analgesic, antipyretic action. Ascorbic acid has antioxidant, anti-inflammatory action. Increases the body's resistance to infectious diseases.
Pharmacokinetics: Following oral administration of acetylsalicylic acid, maximum concentration (Cmax) in plasma is achieved within 3 hours.
80-85% of the drug to plasma protein is, the dose increase its plasma protein binding is reduced by up to 50%.
Acetylsalicylic acid metabolism in the liver, in part, the less active metabolites.
Excreted in the urine as unchanged, as well as metabolites.
Urinary excretion of the drug depends on the speed and quality of the PH-.
It is used at temperatures down, pain, body mosadzliereblad flu, fever and other respiratory diseases.
Side effects: In rare cases, it may be noted hipererguli reactions (bronchospasm, skin reactions). _ Rare cases of gastrointestinal bleeding from the blood platelet count (thrombocytopenia).
Allergic reactions, last trimester of pregnancy, lactation, chronic diseases of the stomach and duodenum, increased bleeding tendency, with the concurrent use of anticoagulants. The drug in children and adolescents under 15 years can not be.
"Neospirini + z" _ the powder can not be used in children because of the risk of flight syndrome.
Caution: The drug precautions guards to use anticoagulant related treatment, gout, gastric and / or duodenal ulcer disease (history), erosive gastritis, gastrointestinal tract bleeding tendency, hipotrombinemiis, K hipovitaminozis, anemia, the body fluid containment conditions (including functional disorders of the heart, blood pressure), thyrotoxicosis.
Drug Interactions with other drugs: Methotrexate toxicity increases, narcotic analgesics, other anti-inflammatory drugs, oral hypoglycemic drugs, heparin, indirect anticoagulants, thrombolytic and aggregation inhibitors tombotsitebis, sulfonamides (including trimoxazole), triiodotironinis, reserpine effects. Reduces urikozuriuli drugs (benzbromaroni, sulfinpyrazone), antihypertensive drugs and diuretics (spironolactone, furosemide) effects.
Steroids, alcohol and alcohol-containing preparations increase the gastrointestinal mucosa damaging effect, increase the risk of bleeding in the gastrointestinal tract. Increases digoxin, barbiturates and lithium concentration in blood plasma.
Ascorbic acid improves the intestinal absorption of iron preparations.
Dosage: sparkling powder should be dissolved in 100 ml of hot water for making ago. Solution should be taken orally.
Adults: 1-2 The powder 3 times a day.
Adolescents from 15: 1 The powder 3 times a day.
Pregnancy and lactation: in pregnancy (especially l and lll trimester) and lactation is not allowed without consulting a doctor.
Influence of vehicle and mechanisms management: Preparation does not affect the ability to drive or to focus on the management of mechanisms.
Form: 2 g effervescent powder package. 10 pack in a cardboard box with instruction.
Shelf life: 2 years.
Visual defects and after expiry of the preparation can not be!
Storage: Store in a dry, dark place, 8-15º C temperature conditions.
Pharmacy Issue: pharmaceutical product group III - issued without prescription.

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