Neovit D3 2000 IU, 30 tablets

Instructions for use

**NEOVIT D3 – 2000 IU; 5000 IU** **NEONEOVIT D3 – 2000 IU; 5000 IU** **Pharmacological Group:** Food supplement (source of a single vitamin). **International Nonproprietary Name (INN):** Cholecalciferol. **Composition per tablet:** One tablet of “NEOVIT D3” 2000 IU contains 50 μg of vitamin D3 (cholecalciferol). One tablet of “NEOVIT D3” 5000 IU contains 125 μg of vitamin D3 (cholecalciferol). **Excipients:** Lactose, dibasic calcium phosphate, starch, povidone, α-tocopherol, magnesium stearate. The product contains no preservatives or colorants and is GMO-free. **Recommended Use:** Recommended for use as a food supplement and an additional source of vitamin D3 (cholecalciferol) to help maintain optimal vitamin D levels in the body. **Description:** “NEOVIT D3” contains vitamin D3, an essential vitamin required for the normal functioning of virtually all organs and systems of the human body. Following oral administration, vitamin D is absorbed almost completely (up to 80%) in the distal part of the small intestine due to the formation of micellar complexes. Maximum concentration (Cmax) in tissues is reached after 4–5 hours, after which the concentration decreases slightly and remains at a relatively stable level for an extended period. **The Role of Vitamin D in Vital Physiological Processes** Vitamin D is used as an adjunct in complex therapy. **Skeletal System** Vitamin D participates in the regulation of calcium and phosphorus metabolism. It promotes intestinal calcium absorption, regulates calcium and phosphorus levels in the blood, and activates bone metabolism. It contributes to increased bone strength and reduces the risk of developing rickets and osteomalacia. Maintaining normal vitamin D levels is important at any age, particularly in older adults, when the risk of falls and injuries increases. Vitamin D supports dental health by stimulating the formation of dentin, a major structural component of teeth, and may reduce the risk of dental caries. **Endocrine System** Vitamin D participates in the regulation of the function of virtually all endocrine glands. **Carbohydrate and Lipid Metabolism** Vitamin D contributes to the regulation of carbohydrate and lipid metabolism and has a beneficial effect on glucose and insulin metabolism. Vitamin D deficiency is considered a risk factor for the development of insulin resistance. Vitamin D contributes to the reduction of blood cholesterol, low-density triglycerides, and lipid levels and plays an important role in the management of obesity and metabolic disorders. Vitamin D inhibits lipid oxidation processes. **Cardiovascular System** Vitamin D has a beneficial effect on vascular walls and blood coagulation processes, influences the renin–angiotensin system, participates in the regulation of blood pressure, and contributes to the normalization of vascular tone. **Musculoskeletal System** Vitamin D contributes to improved muscle strength and neuromuscular transmission, thereby reducing the risk of falls and fractures. **Immune System** Vitamin D contributes to the maintenance of healthy immune function through effects on both innate and adaptive immunity. It activates the synthesis of endogenous antimicrobial substances in cells of the skin, respiratory tract, and gastrointestinal tract, thereby helping to reduce the risk of respiratory illnesses (common colds). Vitamin D regulates the synthesis of substances by immune cells, including anti-inflammatory mediators, which contribute to the suppression of inflammatory processes in the body. **Reproductive System** Vitamin D stimulates the synthesis of female and male sex hormones, including estrogens, progesterone, and testosterone. It has a beneficial effect on reproductive function in both women and men. Studies have established that maternal intake of vitamin D3 during pregnancy may reduce the risk of developing obstructive pulmonary disease in children. **Nervous System** Vitamin D participates in regulatory processes within the nervous system and has a beneficial effect on cognitive functions, including memory, concentration, information processing, and work capacity. Vitamin D exerts neuroprotective effects and plays an important role in the mechanisms protecting the brain from injury. Through its involvement in the conversion of tryptophan to serotonin, vitamin D contributes to mood regulation. **Skin** Vitamin D contributes to the intensification of metabolic processes in the skin and acts as a factor that helps protect the skin against aging. **Digestive System** Vitamin D has a beneficial effect on gastrointestinal mucosal homeostasis and contributes to the protection, maintenance, and restoration of epithelial barrier integrity. Through its effects on immune cell function, it contributes to the suppression of autoimmune inflammatory processes in the intestine. **Regulation of Energy Metabolism** By regulating cellular energy potential, vitamin D contributes to reducing fatigue and improving overall vitality. Under the influence of vitamin D, ATP production in cellular mitochondria increases. ATP is the universal energy source for all biochemical processes occurring in the body. **Regulation of Cellular Growth** Vitamin D regulates cellular growth, development, and renewal. Vitamin D3, commonly known as the “sunshine vitamin,” is synthesized in human skin under exposure to ultraviolet radiation and is subsequently converted in the liver and kidneys into its active form, 1,25-dihydroxycholecalciferol. Another natural source of vitamin D3 is food. The richest dietary sources include fish, eggs, liver, and mushrooms. Due to spending most of the time indoors, the body may not produce sufficient amounts of vitamin D3, resulting in vitamin D3 deficiency. In individuals over 65 years of age, the ability of the skin to synthesize vitamin D is also reduced due to age-related changes in the skin. To ensure an adequate supply of vitamin D3 regardless of the season and exposure to sunlight, supplementation from an additional source is recommended. Regular use of “NEOVIT D3” 2000 IU and 5000 IU helps replenish the body’s vitamin D stores over an extended period. **Indications:** Used as an adjunct in complex therapy. “NEOVIT D3” is recommended: * to maintain normal vitamin D levels; * to strengthen bones and teeth; * to support immune function; * to reduce fatigue and improve vitality; * to support muscle strength; * to improve concentration and memory; * to support reproductive function. **Method of Administration and Dosage:** The tablet should be taken before meals with plenty of water. The duration of use depends on the level of vitamin D in the blood. Consultation with a physician is recommended to determine the appropriate duration of use. **Dosage of “NEOVIT D3” 2000 IU Tablets:** Children aged 3 to 12 years: 1 tablet every other day. Children over 12 years of age and adults: 1 tablet once daily. **Dosage of “NEOVIT D3” 5000 IU Tablets:** Children and adolescents aged 11 to 17 years: 1 tablet once weekly. Adults over 17 years of age: 1 tablet every other day. **Precautions:** Do not exceed the recommended dosage. Food supplements should not be used as a substitute for a varied and balanced diet. The recommended maximum daily dose for adults and elderly individuals is 4000 IU (100 μg/day). If necessary, the daily dose may be increased following consultation with a physician. During pregnancy and lactation, an adequate supply of vitamin D3 is required. Excessive intake may adversely affect the health of both the mother and the child. During pregnancy, vitamin D3 should be taken only on the recommendation of a physician. **Adverse Effects:** Allergic reactions and signs of hypervitaminosis may occur. **Overdose:** Symptoms of overdose may include loss of appetite, nausea, vomiting, constipation, anxiety, thirst, diarrhea, headache, sleep disturbances, and elevated body temperature. **Management:** Discontinue use of the product and consult a physician. Drink plenty of fluids. **Contraindications:** Do not use in case of hypersensitivity to any of the components of the food supplement or in patients with a history of celiac disease. **Presentation:** **Primary packaging:** 10 tablets in a PVC/Alu blister pack. **Secondary packaging:** 3 blisters are placed in a carton together with the package leaflet. **Dispensing Category:** Pharmaceutical product Group III; available without a prescription. **Shelf Life:** 2 years. **Storage Conditions:** Store in a dry place protected from light at a temperature not exceeding 25°C. **Manufacturer:** LLC “Neopharm” Georgia, Tbilisi, David Aghmashenebeli Alley, 12th km Tel./Fax: +995 (032) 259-64-46, 259-57-90.